Best CRMs for Drip Campaigns 2025

Drip campaigns are automated email sequences that nurture leads and drive sales. For U.S. businesses, the right CRM makes them easy, effective, and scalable. Here are the top 7 CRMs for drip campaigns in 2025—clear, simple, and built for American users.

Why Drip Campaigns Matter in the U.S.

Personalized drips get 20-30% open rates vs. 15% for bulk emails. U.S. businesses using automation see up to 80% better retention. From e-commerce in Texas to SaaS in Seattle, drips turn leads into loyal customers.

Must-Have CRM Features

Drag-and-drop workflow builder

Smart segmentation (location, behavior)

Personalization (name, past actions)

A/B testing and analytics

Shopify, Stripe, Zapier integrations

Mobile app and U.S. support

CCPA-compliant tools

Now, the best CRMs for drip campaigns.

1. ActiveCampaign – Best Overall

Chicago-based. No-code automation with if/then logic.

Starts: $29/month (500 contacts)

Best for: Small to mid-sized U.S. businesses

Win: Site tracking + predictive send times

A Florida store got 35% more conversions from cart recovery drips.

2. HubSpot – Best Free Start

Boston-born. Free CRM with solid drip tools.

Starts: Free (2,000 emails/month)

Best for: Startups and inbound teams

Win: Lead scoring + free training

A New York agency boosted pipeline 50% with smart sequences.

3. Klaviyo – Best for E-Commerce

Boston. Built for Shopify and online stores.

Starts: Free (250 contacts)

Best for: U.S. e-commerce brands

Win: Revenue tracking per email

A Denver brand lifted repeat sales 25% with birthday drips.

4. Mailchimp – Best for Beginners

Atlanta. Simple, fast, beginner-friendly.

Starts: Free (500 contacts, 1,000 emails)

Best for: Solopreneurs and small shops

Win: AI subject lines + pre-built journeys

A Texas bakery spiked holiday sales 40%.

5. Keap – Best for Service Pros

Scottsdale. Sales + drip automation in one.

Starts: $199/month

Best for: Coaches, agencies, local services

Win: Appointment booking in emails

A Miami firm cut sales cycles 30%.

6. Zoho CRM – Best Budget Pick

Popular in U.S. for value and power.

Starts: Free (3 users), $14/user paid

Best for: Growing teams on a budget

Win: AI suggestions + mobile app

A Chicago startup saved 60% and grew leads 20%.

7. Salesforce – Best for Big Business

San Francisco. Enterprise-grade with AI.

Starts: $25/user/month

Best for: Large U.S. companies

Win: Omnichannel + deep reporting

A Detroit firm saw 45% engagement lift.

Quick Pick Guide

Solo/Beginner: Mailchimp

E-Commerce: Klaviyo

Small Business: ActiveCampaign

Free Start: HubSpot

Service/Sales: Keap

Budget Team: Zoho

Enterprise: Salesforce

How to Choose

Test with a 14-day trial

Start with one drip (welcome or cart recovery)

Check U.S. support and compliance

Scale only what works

Final Tip

Start simple. One good drip beats ten messy ones. Pick a CRM above, send your first sequence this week, and watch leads turn into revenue.